Ysa started involving with the art activism in 2000 when she volunteered for the Vietnamese American Arts & Letters Association (VAALA), a non-profit 501 (c)(3) organization. Since then, she has produced and co-produced many events such as Dang Thai Son Piano Recital; Little Saigon Book Fair I; F.O.B. I: A Multi-Art Show and F.O.B. II: Art Speaks; the biennial Cinema Symposium 1, 2, 3, and 4 at the University of California, Los Angeles. In 2003, Ysa co-founded the biennial Vietnamese International Film Festival (ViFF), which was held mainly at the University of California, Irvine (UCI). Since 2003, ViFF has been established as an important forum for the filmmakers of Vietnamese descent. The event has been extensively covered by both domestic as well as international press and well received by thousands of audience members from all over the country.

Ysa served as VAALA’s Board President from 2004-2008. She is currently VAALA’s Executive Director. She recently developed smART Program, which provides free art workshops to non-profit youth organizations in the Orange County and Los Angeles areas.

In 2005, Ysa was chosen by the Orange County Register as one of the “30 Vietnamese Americans to Watch” in celebrating the 30th anniversary of the Vietnamese American community in the United States.

Since 2001, Ysa hosts "Vòng Chân Trời Văn Học Nghệ Thuật" ("The Art Horizon"), a weekly program on VNCR 106.3 FM reporting art events in the community and interviewing the artists. She received the Arts and Culture (In-Language) Award from New California Media in 2003 for her article on Mimi News reporting the revival of the traditional performing art Cai Luong in the Vietnamese community.

Graduated from the University of Southern California, School of Pharmacy in 1994, Ysa currently works as a pharmacist at St. Joseph Home Care Pharmacy in Orange, California.